Based on annotation using eFORGE v2.0 (https://eforge.altiusinstitute.org/) [39, 40], positions of the 509 novel AD-associated CpG sites were overlapped with regions containing lysine 4 mono-methylated H3 histone (H3K4me1) markers across 36 of 39 cell types in the consolidated Roadmap Epigenomics Project, including blood (primary T cells from cord blood and peripheral blood, primary B cells, natural killer cells and monocytes from peripheral blood, and primary hematopoietic stem cells G-CSF-mobili) (Supplementary Fig. S3). Here, CSF3 is linked to Alzheimer disease.