It’s worth noting that for 14 genes, namely, DGKQ, CR1, CPSF3, INPP5D, SERPINB1, MAFK, TMEM184 A, PARP10, RNF43, UBASH3B, BCKDK, PVR, NKPD1, and CASS4, there were inconsistent directions of associations for the DNA methylation-gene expression-AD risk pathway (Supplementary Table S5). The gene discussed is RNF43; the disease is Alzheimer disease.