SLC6A4, COMT, HTR1B, and HTR2A were linked to responses to drug/psychotherapy, PDE4B, NTRK2 and NPSR1 to DSM-guided binary diagnosis of anxiety and/or composite anxiety measures, CRHR1 to neuroticism (AD-associated personality trait) and NPY to neural activation patterns in response to anxiety-inducing stimuli [7, 8]. This evidence concerns the gene PDE4B and Anxiety.