STK11 and glioblastoma: Nonetheless, regardless of the dose or timing of the effects produced in anchorage-dependent GBM cells and neurospheres, CPZ treatment led to a constant increase of the autophagic response, i.e., increased phosphorylation of LKB1 pS428, AMPK-α pT172 and Ac-CoA Carboxylase pS79 (Fig. 1A), which appears consistent with our previous report [13].