Hypoxia (0.2% O2, 48 h) decreases Hippo kinases, except NDR2, without changing the methylation status of the promoters of their genes or of the target gene of YAP, ANKRD1, known to be inactivated/hypermethylated in NSCLC [8, 22] (HBEC-3: Fig. S7A, A549: Fig. S7B). The gene discussed is YAP1; the disease is non-small cell lung carcinoma.