The H-Score of carbonic anhydrase 9 (CAIX), a transcriptional target of HIF-1A [20], is similar between primary tumors of patients with localized NSCLC (62.4 ± 12.3) or metastatic NSCLC (71.2 ± 19.7), and comparable between primary tumors and brain metastasis (65.4 ± 17.1, n = 20) from the same patients (Fig. S1). This evidence concerns the gene CA9 and non-small cell lung carcinoma.