KDR and liver dysplastic nodule: Mice treated with anti-VEGFR2 F(ab′)2 and anti-VEGFR2 F(ab′)2-SS31 had lower macrophage fluorescence and a higher ratio of M1/M2 macrophage (4.4 and 4.4 respectively) than DN mice that were not treated or were administered SS31 (~3.0), indicating that anti-VEGFR2 F(ab′)2 and anti-VEGFR2 F(ab′)2-SS31 effectively inhibited the DN progression and precancerous changing.