The levels of TGF-β1 and CTGF obviously increased in DN kidney, and decreased significantly after anti-VEGFR2 F(ab′)2 and anti-VEGFR2 F(ab′)2-SS31 treatments, which was coincident with the results mentioned above, indicating the effective anti-fibrosis ability of anti-VEGFR2 F(ab′)2 and anti-VEGFR2 F(ab′)2-SS31. The gene discussed is CCN2; the disease is liver dysplastic nodule.