FUS and frontotemporal dementia: In addition, TDP-43 and FUS proteins, two RNA-binding proteins present in pathological aggregates in ALS (TDP-43 in >97% of cases33) and FTD (TDP-43 in approximately 40% of cases34 and FUS in approximately 10% of cases35), have both shown G4-binding abilities, reinforcing the idea that G4s might play a key role in the formation of condensates typical of ALS/FTD36–38.