LRAT and Hepatic fibrosis: Mederacke et al. provide heretofore the most elegant and comprehensive fate-mapping data to show that hepatic stellate cells (HSCs), labeled by lecithin-retinol acyltransferase (Lrat) represent the predominant source of ECM-producing myofibroblasts in well-established models of liver fibrosis induced by injection with CCl4 or thioacetamide, bile duct ligation, or feeding with 3,5-diethoxycarbonyl-1,4-dihydro-collidin diet or methionine-and-choline deficient diet [6].