The potential beneficial effects of ER-β activation have also been noted as being neuroprotective in models of brain injury (Chakrabarti et al. 2014; Guo et al. 2020) and in improving mitochondrial function in the presence of soluble amyloid oligomers (Sarkar et al. 2015), as well as having an anxiolytic effect (Hughes et al. 2008). Here, ESR2 is linked to injury.