CD8+ T cells have a pivotal role in the host adaptive immune response against viral infection.94,95 Before activation of an effective CD8+ adaptive cellular response, the host must overcome resistance from HSV-1, which expresses an immediate-early protein, ICP47.96 ICP47 functions to prevent migration of antigenic peptides and causes MHC-I accumulation within the endoplasmic reticulum. The gene discussed is CD8A; the disease is viral infectious disease.