CD4+ T cells have the ability to restrict and eliminate acute HSV infection but also regulate the host immune response.100 Interestingly, in the HSV-1 corneal infection model, upon activation by local dendritic cells, naïve HSV-specific CD4+ T cells undergo expansion and CD4+ T effector cells are restimulated within draining lymph nodes.106 The purpose of this immune arborization is thought to regulate the local deleterious effects of inflammation. Here, CD4 is linked to corneal infection.