Moreover, our analysis also revealed a similar trend towards high levels of RA autoimmunity (aOR = 1.59; 95% CI: 0.85, 2.81), which was significant only with high levels of ACPA, in an exploratory analysis (aOR = 2.88; 95% CI: 1.08, 6.91). Here, PRTN3 is linked to Autoimmunity.