In particular, homologs AKT1 [94], AKT2 [95], ERBB2 [96], FGFR2 [97], and PIK3CA [98] in CGC play important roles in breast cancer progression, mediating breast cancer risk, corresponding to the driver candidates RPS6KA1, SGK1, PTK2, IGF1R, PIK3CB, and PRKDC predicted by DriverMP. This evidence concerns the gene PRKDC and breast carcinoma.