TLR4 is highly expressed in NSCLC tumor cells and strongly correlates with malignant tumor phenotypes. TLR4 ligation promotes the secretion of immunosuppressive cytokines TGF-β, VEGF, and proangiogenic chemokine IL-8 from human lung cancer cells [121, 122]. This evidence concerns the gene CXCL8 and non-small cell lung carcinoma.