PRKDC and breast cancer: In particular, homologs AKT1 [94], AKT2 [95], ERBB2 [96], FGFR2 [97], and PIK3CA [98] in CGC play important roles in breast cancer progression, mediating breast cancer risk, corresponding to the driver candidates RPS6KA1, SGK1, PTK2, IGF1R, PIK3CB, and PRKDC predicted by DriverMP.