In addition, by overlaying the cRE–gene covariability map and TF binding motif data along the genome axis, we revealed a potential cis-regulatory relationship of pathogenic genes specific to AST4, such as SLC39A12, in neurodegenerative diseases such as Alzheimer's disease (Fig. 3H) [57]. This evidence concerns the gene TF and early-onset autosomal dominant Alzheimer disease.