We found that primate-specific DEGs were enriched in different pathways in the AST of the SN, including APC, ITPR2, and PIK3R1, which are related to Alzheimer's disease, as well as ERBB4, FGFR1 and FYN, which are associated with diseases related to signal transduction by growth factor receptors and second messengers (Fig. 4F) [64, 65]. The gene discussed is ERBB4; the disease is early-onset autosomal dominant Alzheimer disease.