Five patients (14%) additionally harbored PVs in other genes associated with BC risk, including ATM (c.1027_1030del, p.E343Ifs and c.237del, p.Lys79fs), PALB2 (c.2827_2830del, p.E943Sfs), RAD50 (c.2517dupA, p.D480fs) and MUTYH (c.536A > G, p.Y179C) (Supplementary Table S1). The gene discussed is ATM; the disease is breast cancer.