Also, Myricetin acts against diabetes by stimulating lipogenesis in adipocytes and increasing the stimulatory effect of insulin, suppressing the α-glucosidase activity, enhancing the antioxidant defense system, anti-aldose reductase, and insulin resistance (Imran et al., 2021), and protecting the β-cells against HG-induced fatality by preventing ER stress, presumably by the inactivation of CDK5 and subsequent overexpression of PDX1 and SER A2b (Karunakaran et al., 2019). This evidence concerns the gene AKR1B1 and diabetes mellitus.