PDX1 and diabetes mellitus: Also, Myricetin acts against diabetes by stimulating lipogenesis in adipocytes and increasing the stimulatory effect of insulin, suppressing the α-glucosidase activity, enhancing the antioxidant defense system, anti-aldose reductase, and insulin resistance (Imran et al., 2021), and protecting the β-cells against HG-induced fatality by preventing ER stress, presumably by the inactivation of CDK5 and subsequent overexpression of PDX1 and SER A2b (Karunakaran et al., 2019).