Additionally, the prioritization analysis indicated that a couple of genes were already associated with “Neurodegeneration.” NIPA1, which was hypermethylated, has been reported as a common risk factor for ALS, where the expansion of the repetition unit motif GCG > 8 has been linked to an increased risk of the disease (Tazelaar et al., 2019), but associations with its methylation status were not investigated. This evidence concerns the gene NIPA1 and amyotrophic lateral sclerosis.