To study epidemiological, clinico-radiological profile and changes in levels of certain primarily cell-mediated immunity (CMI)-specific cytokines [Tumour Necrosis Factor-beta (TNF-β), Interferon-gamma (IFN-γ)] and Interleukin-6 (IL-6)] in cases of rhinosporidiosis, in a tertiary health care center in Chhattisgarh. The gene discussed is IFNG; the disease is rhinosporidiosis.