GPNMB and Miyoshi myopathy: In the brain, we identified 3 MM subtypes: BrMM0, the classical MM with a Ly6c+Ccr2hi profile; BrMM1, showing a preference for antigen-presentation genes; and BrMM2, distinguished by Gpnmb and Trem2 markers (Fig. 3F and G and Fig. S3B and C).