GPT and metabolic dysfunction-associated steatohepatitis: Hepatic triglyceride (TG) content, hepatic lipid peroxide levels, and serum alanine transaminase (ALT) levels were all lower in DDX3XΔMφ mice fed the HFHC diet for 12 weeks than in DDX3Xfl/fl mice (Fig. 2D), suggesting that macrophage DDX3X exacerbated the development of NASH.