In contrast to vaccination of a cohort of healthy participants, patients with hematological malignancies who had a lower anti-Spike response, also had a diminished systemic cytokine response (IFN-γ, IL-15 and CXCL10/IP-10), and this correlated with the lower anti-Spike antibody levels (11). This evidence concerns the gene CXCL10 and hematologic disorder.