LINC00273 recruits neuronally expressed developmentally downregulated 4 (NEDD4) to promote LATS2 ubiquitination and degradation, and activates YAP, thereby inactivating the Hippo pathway, and M2-polarized macrophages promote lung adenocarcinoma (LUAD) cell invasion and migration and tumor metastasis in vivo (46). This evidence concerns the gene YAP1 and lung adenocarcinoma.