To investigate the B cell intrinsic role of MHC haplotype in the context of autoimmunity, we crossed the 564Igi autoreactive B cell receptor knock-in line (10), which was available on C57BL6/J (B6), i.e., H2b/b background, to the B6.C-H2d/bByJ line (B6.H2d). This evidence concerns the gene HLA-C and Autoimmunity.