CD4+ Th1 cells, CD8+ T cells, NK cells, IFN-γ, M1 macrophages uninterruptedly function to be anti- tumor, while regulatory T cells (Treg), M2 macrophages, Th17 cells, overexpression of TGF- β, and IL- 10 facilitates immune evasion of the tumor cells (5, 44). The gene discussed is CD4; the disease is neoplasm.