Recent examples showed overexpression of CXCR2 enhanced infiltration of CAR-T hepatocellular carcinoma xenografts where the tumors were shown to express high levels of CXCR2 ligands including CCL2, CXCL1, CXCL2, and CXCL5 (89); CXCR1 overexpression enhanced T and NK CAR cells to migrate into ovarian or pancreatic tumors (90, 91) and CCR2 transduction into MSLN CAR-T cells enhanced migration into CCL2 positive malignant pleural mesotheliomas (86, 92). The gene discussed is CCL2; the disease is malignant pleural mesothelioma.