Potential target antigens for CAR-T cells in AML include CD7 (110, 115), CD33/Siglec-3 (116, 117), CD38 (67, 111), CD41 (118), CD44 (119), CD64 (120), CD70 (121–123), CD117 (124), CD123 (125), CLL-1 (112, 114, 126, 127), B7-H3 (128), PR1 (129), FLT3 (130–132), IL1-RAP (133, 134), Siglec-6 (135), NKG2D (136), PRAME (137), and GRP78 (138). This evidence concerns the gene CD44 and acute myeloid leukemia.