FCER1G and cancer: incorporated the intracellular signaling domains from FcRγ (Fc receptor γ), Megf10 (multiple EGF-like domains protein), and PI3K (phosphoinositide 3-kinases) respectively in CAR, and showed that CAR-Ms with the FcRγ intracellular domain were more powerful in phagocytizing and killing cancer cells (43).