IL18 and serum lipopolysaccharide activity: Like NLRC4V341A/V341A mice, these NLRC4T337S mice showed elevated IL-18 levels without detectable inflammatory pathologies and were not more susceptible to various challenges such as endotoxemia, Dextran Sodium Sulfate colitis, and infection with abortive or chronic Lymphocytic Choriomeningitis Virus (14).