To more specifically evaluate NLRC4V341A effects in a gastrointestinal infection model leading to IL-18 production from IECs, we infected NLRC4V341A/V341A mice with C. rodentium, as NLRC4 responses in non-hematopoietic cells were shown to restrict colitis induced by this enteropathogen (26). Here, NLRC4 is linked to digestive system infectious disorder.