HMLER-derived CSC-like cells in the BC scenario are resistant to γδ T-cell-mediated killing, but inhibition of farnesyl pyrophosphate synthase results in MHC-I and CD54/ICAM-1 upregulation, which increases the susceptibility to γδ T-cell- and CD8+ T-cell-mediated lysis (71). This evidence concerns the gene ICAM1 and breast cancer.