High-risk ccRCC patients exhibited an increase in tumor sample infiltration by plasma cells, activated memory CD4 T cells, Tfh cells, Tregs, and M0 macrophages, whereas low-risk patient samples exhibited infiltration by higher levels of resting memory CD4 T cells, resting NK cells, M2 macrophages, resting DCs, activated DCs, and resting mast cells. The gene discussed is CD4; the disease is nonpapillary renal cell carcinoma.