The same observations were made with HER2 specific CAR T cells in a xenograft mouse model of HER2low osteosarcoma, with B7-H3 specific CAR T cells in a model of B7-H3low neuroblastoma, and with glypican-3 specific CAR T cells in a model of glypican-3low neuroblastoma (34). The gene discussed is GPC3; the disease is neuroblastoma.