Moreover, in mice simultaneously engrafted with GPC2high and GPC2low neuroblastoma cells with 10,000 versus 5,000 GPC2 molecules per cell, CAR T cells coexpressing c-Jun completely eradicated neuroblastoma cells in a lasting fashion whilst canonical CAR T cells targeted GPC2high neuroblastoma cells while leaving GPC2low cells untouched (46). This evidence concerns the gene JUN and neuroblastoma.