Anti-sense oligonucleotides in familial amyotrophic lateral sclerosis (fALS): In the brain and spinal cord of SOD1-rats, it was shown that intracerebroventricular injections of ASO against SOD1 directly decreased SOD1 mRNA through RNase H activity, extending the rats' mean lifetime by 10 days. Here, SOD1 is linked to familial amyotrophic lateral sclerosis.