AKT1 and breast carcinoma: When GEF is used for the treatment of EGFR2 overexpressing tumors, it results in dephosphorylation of EGFR2 and strong downregulation of PI3k/Akt signaling connected to dephosphorylation of EGFR3, which indicates the potential of GEF to be employed for EGFR2 overexpressing breast cancers in addition to EGFR overexpressing breast cancers.