KLEFS-2 (OMIM 617768) is a rare genetic disorder associated with mutations in the KMT2C gene, characterized by individuals exhibiting intellectual disability, childhood hypotonia, autistic-like features, and distinctive facial features (Koemans et al., 2017; Lavery et al., 2020; Siano et al., 2022). The gene discussed is KMT2C; the disease is Intellectual disability.