TNC and stroke disorder: Similarly, tenascin-C is found in the extracellular matrix and is associated with poor prognosis in stroke due to its neuroinflammatory properties (Zaidi et al., 2019; Okada and Suzuki, 2020), while CRP, a commonly used clinical marker for non-specific general inflammation, did not correlate with futile recanalization (Zang et al., 2020).