Four factors, namely, interleukin-2 receptor subunit alpha levels (OR = 0.9974, 95%CI: 0.9958–0.9989, p = 0.0010), interleukin-11 receptor subunit alpha (OR = 0.9970, 95%CI: 0.9944–0.9996, p = 0.0250), interleukin-27 (OR = 0.9977, 95%CI: 0.9956–0.9999, p = 0.0385), and interleukin-31 (OR = 0.9978, 95%CI: 0.9959–0.9996, p = 0.0189), were inversely associated, indicating a potential protective effect against hypertension (Figure 3; Supplementary Figures S7–S9). The gene discussed is IL31; the disease is Hypertension.