Both ORAI1 and STIM1 play a role in promoting survival and apoptosis resistance in pancreatic adenocarcinoma cell lines. SiRNA-mediated knockdown of ORAI1 and/or STIM1 increases apoptosis induced by the chemotherapy drugs 5-fluorouracil (5-FU) and gemcitabine. Singh et al. (2020). Here, STIM1 is linked to pancreatic adenocarcinoma.