The SOCE is decreaed in STIM1 knockdown and Orai1 knockdown thyroid cancer cells. This resulted in decrease in thyroid cancer cells proliferation. In xenograft zebrafish model, the STIM1 knockdown decreaed human thyroid tumor growth and also activated apoptosis. Asghar et al. (2021). This evidence concerns the gene STIM1 and thyroid cancer.