For instance, the susceptibility to simple steatosis or MASH is heightened by mutations in various genes responsible for governing lipid metabolism, such as patatin-like phospholipase domain 3 (PNPLA3), transmembrane 6 superfamily member 2 (transmembrane 6 superfamily member 2, TM6SF2), farnesyl diphosphate farnesyl transferase 1 (FDFT1), and membrane-bound o-acyl transferase domain containing 7 (MBOAT7) (15) (Figure 1). The gene discussed is TM6SF2; the disease is metabolic dysfunction-associated steatohepatitis.