Compared with the study conducted by Cao et al., the current study had significant differences in the study population; in addition, the optimal threshold of ALT/HDL-C ratio for diabetes prediction should also be noted: compared with the Japanese population, the current study calculated that the optimal threshold for predicting diabetes is relatively lower (14.9248 vs 17.56), which also suggests that the Chinese population may need more stringent standards in future diabetes risk assessment/prediction. The gene discussed is GPT; the disease is diabetes mellitus.