Furthermore, Cong et al., 2019 found that high specific volume polysaccharide, as a new type of dietary fiber, could regulate intestinal water metabolism in constipated rats by lowering the colonic AQP3 expression via cAMP-PKA pathway, and highlighted important role of the brain-gut-microbiome axis in the pathogenesis of constipation. Here, AQP3 is linked to Constipation.