Moreover, latent membrane protein 2A (LMP2A) induced the phosphorylation of ERK, which thereby activated DNMT3a transcription and induced loss of AQP3 expression through CpG island methylation of AQP3 promoter in Epstein-Barr virus-associated gastric carcinoma (Wang et al., 2019). This evidence concerns the gene AQP3 and gastric carcinoma.