ATG5 and gastric cancer: The previous in vitro study has also found that AQP3 overexpression promoted the conversion of autophagy-related protein LC3-I to LC3-II and upregulated the ATG5 and Beclin-1 expression in gastric cancer cell line AGS, whereas AQP3 knockdown inhibited the transformation of LC3-I to LC3-II in MGC803 and SGC7901 cells, indicating that AQP3 expression regulated autophagy differently in different gastric cancer cells (Dong et al., 2016).