AQP3 and infection: This might be due to the fact that AQP3 could function as peroxiporin to mediate the entry of extracellular H2O2 into colonic epithelial cells, since defective repair after wounding and impaired H2O2 responses to pathogen infection were observed in both AQP3-deleted Caco-2 cells and AQP3 knockout mice (Thiagarajah et al., 2017).