Previous study has shown that the diffusion and uptake of exogenous H2O2 mediated by AQP3 significantly increased the intracellular reactive oxygen species levels and inhibited rapamycin-induced autophagy via activating the Akt/mammalian target of rapamycin (mTOR) pathway in lung adenocarcinoma cells (Wang et al., 2021). Here, MTOR is linked to lung adenocarcinoma.