Phosphoinositide 3‐kinase (PI3K)/protein kinase B (PKB or AKT)/mammalian target of rapamycin (mTOR) signaling pathway (PAM pathway) is involved in the regulation of tumor cell growth, proliferation, survival, angiogenesis, and so forth, which is important in the pathogenesis and progression of breast cancer [6, 7, 8, 9, 10]. The gene discussed is PIK3CB; the disease is breast carcinoma.