Phosphoinositide 3‐kinase (PI3K)/protein kinase B (PKB or AKT)/mammalian target of rapamycin (mTOR) signaling pathway (PAM pathway) is involved in the regulation of tumor cell growth, proliferation, survival, angiogenesis, and so forth, which is important in the pathogenesis and progression of breast cancer [6, 7, 8, 9, 10]. This evidence concerns the gene PIK3CA and breast cancer.