The XPD rs13181 heterozygote of thymine and guanine/homozygous guanine (TG/GG) genotypes was observed with enhanced glioma risk in astrocytic tumors when compared to homozygous thymine genotypes (adjusted OR = 1.60, 95% CI = 1.02–2.54, p = 0.043). The gene discussed is ERCC2; the disease is central nervous system cancer.