The well‐demonstrated role of mTOR signaling in diverse human cancers [12] and its regulation controlled by ATF4‐induced TNXIP‐stabilized REDD1 [21, 22, 28, 29] prompted us to examine the potential involvement of ATF4/TXNIP/REDD1/mTOR signaling in GW3965‐induced biological activities in pancreatic cancer cells. Here, ATF4 is linked to familial pancreatic carcinoma.