Specifically, we noticed that REDD1 and ATF4 were among the most highly upregulated genes in both pancreatic cell lines, which, together with previous studies showing the crosstalk among ATF4, REDD1, mTOR, and TXNIP [21, 22, 28], prompted us to explore the potential involvement of ATF4/TXNIP/REDD1/mTOR signaling in GW3965‐mediated antiproliferation and pro‐death of pancreatic cancer cells. The gene discussed is MTOR; the disease is familial pancreatic carcinoma.