EDN1 and peritonitis: Similar findings have been reported in the literature, indicating anti-inflammatory effects of Sargassum in LPS-stimulated inflammation in RAW 264.7 cells (Yang et al., 2013 ▶; Kim et al., 2015 ▶; Jayawardena et al. 2019 ▶), Freund's complete adjuvant-induced arthritis model, carrageenan-induced peritonitis model (Neelakandan and Venkatesan, 2016 ▶), endothelin-1 stimulated human keratinocytes (Sah et al., 2013 ▶), and vascular inflammation (Gwon et al., 2017 ▶).