CRH and Alzheimer disease: On the other hand, in postmortem brain tissue from subjects with AD, Behan et al.103 identified the presence of CRH-binding protein (CRHBP) as a factor involved in the decrease of free CRH in individuals with AD and demonstrated that the dissociation of this hormone from CRHBP results in an increase in CRH levels to the values reported in control subjects.