APOE and Alzheimer disease: CSF cortisol levels were significantly higher in subjects with AD (0.82±0.03 ng/mL) compared to control subjects (0.73±0.03 ng/mL) (p<0.05).CSF cortisol concentrations varied in relation to ApoE genotype; both in control subjects (ε3/4>ε3/3>ε2/3) and in subjects with AD (ε4/4>ε3/4>ε3/3) (p<0.05).