CRH and Alzheimer disease: CSF CRH levels were significantly higher in subjects with AD (462±288 pg/ml (range 156–1071 pg/ml)) compared to controls (158±122 pg/ml (range 38-470 pg/ml)) (p<0.01).CSF CRH values in AD subjects were inversely correlated with MMSE score (r=-0.53; p<0.05), but not with CDR scale score or symptom duration.