Finally, her ventricular arrhythmias were controlled with high-dose carvedilol, and she was discharged on hospitalization Day 393.<h4>Discussion</h4>Carvedilol is the only beta blocker that directly acts on the ryanodine receptor (RyR2) and inhibits store-overload-induced Ca<sup>2+</sup> release (SOICR) in myocardium at high dosage. Here, RYR2 is linked to Ventricular arrhythmia.