PTGS2 and cancer: A high rate of chemotherapy unresponsive cases ofovarian cancerexhibits increased expression levels of cyclooxygenase-2 enzyme (COX-2),suggesting that COX-2 involves pathways associated with chemotherapysensitivity of this cancer type.6 Non-steroidalanti-inflammatory drugs (NSAIDs) are known to repress prostaglandin(PG) production, and their activity as a COX-2 inhibitor was demonstratedin clinical studies.7 Naproxen, a well-knownNSAID, and Naproxen-derived compounds (NDCs) recently have been investigatedfor their anticancer activities8−14