AKT1 and Cerebral ischemia: Several studies have found that intravenous injection of Salvianic acid A can inhibit caspase-3/7 activity by activating the PI3K/Akt signaling pathway to regulate the expression of apoptotic genes Bax and Bcl-2 (Guo et al., 2015), inhibiting the phosphorylation of AKT1 and mTOR by activating AKT1 to reduce the rate of nerve cell apoptosis or improving the neurological dysfunction and pathological morphology in brain tissues of damaged areas, in turn alleviating cerebral ischemia tissue reperfusion injury (Yu et al., 2014; Yu et al., 2015; Zhang et al., 2019).