This is related to the role of ACE2 and the renin–angiotensin–aldosterone system (RAAS) in the reduced exacerbation of comorbidities, such as cardiovascular diseases, hypertension, and respiratory distress syndrome, in which the RAAS plays a protective role and its levels define the severity of COVID-19 (Plebani and Lippi, 2022). This evidence concerns the gene ACE2 and COVID-19.