G3BP1 and malignant colon neoplasm: Reportedly, G3BPs interact with HDAC6, which is a core component of stress granules, and AKAP12 binds to HDAC6 in human colon cancer cells.[32] Our results demonstrated that HDAC6 was significantly downregulated in G3BP dKO cells, suggesting that G3BPs can modulate HDAC6 expression.