TREM2 and osteoporosis: Furthermore, loss‐of‐function mutations of TREM2 are seen in the context of Nasu‐Hakola disease (NHD), a human disease characterized by osteoporotic features leading to recurrent bone fractures associated with pre‐senile dementia.[55] Patients with NHD present osseous symptoms typically at a young age (between 20 and 30 years), where impairment in TREM2+ signaling may disrupt the coupling of bone resorption and formation, leading to low turnover osteoporosis.