ITGAE and cancer: Genes that regulate memory T cell trafficking were less abundant, such as ITGAE (Figure 3i),[36] while genes that might predict increased responsiveness to the inflammatory milieu (e.g., STAT4 and CCR2) were downregulated in human TVM cells (Figure 3i).[34] In addition, aged human TVM cells exhibited a lower score of exhaustion but a relatively higher score of senescence compared to other memory cells (Figure 3j).[37] T cell exhaustion is a state of T cell dysfunction that arises during many chronic conditions and cancer.