Given the importance of TREM2+ Macs in various diseases, including obesity, Alzheimer's disease, and cancer, numerous efforts are underway to pharmacologically target TREM2 signaling.[18] Our study highlights a novel possibility that harnessing the TREM2 function might have beneficial effects on the aging phenotypes of M&B units beyond the aforementioned contexts. This evidence concerns the gene TREM2 and early-onset autosomal dominant Alzheimer disease.