Similarly, in mice with metabolic‐associated fatty liver disease, Trem2+ Macs were found in the fibrotic zone and expressed genes involved in fibrosis, such as Spp1 and Des, suggesting a role in the mechanism of steatohepatitis.[24] Consistent with our findings, blockade of TREM2 inhibited bone resorption, and TREM2 stimulation enhanced the formation of mature osteoclasts that were generated from bone marrow macrophages or RAW264.7 cells treated with receptor activator for nuclear factor κ B Ligand (RANKL) and macrophage colony‐stimulating factor 1 (M‐CSF1). This evidence concerns the gene DES and fatty liver disease.