IL1B and Autoimmunity: The exact mechanism of autoimmunity in PD remains unclear.1 Thymic hyperplasia in the present patient may indicate a defect in central tolerance.11 Consistent with previous reports,3 5 the present patient displayed elevated serum levels of IL-18, suggesting increased inflammasome activation, which was confirmed by the higher LPS and ATP-induced IL-1β secretion by patient-derived monocytes.